TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES
\tɹansmˈɪsəbə͡l spˈʌnd͡ʒɪfˌɔːm ɛnsˌɛfɐlˈɒpəθɪz], \tɹansmˈɪsəbəl spˈʌndʒɪfˌɔːm ɛnsˌɛfɐlˈɒpəθɪz], \t_ɹ_a_n_s_m_ˈɪ_s_ə_b_əl s_p_ˈʌ_n_dʒ_ɪ_f_ˌɔː_m ɛ_n_s_ˌɛ_f_ɐ_l_ˈɒ_p_ə_θ_ɪ_z]\
Sort: Oldest first
-
A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA, ataxia, and a fatal outcome. Diseases in this category include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER-SCHEINKER SYNDROME; KURU; SCRAPIE; fatal familial insomnia; bovine spongiform encephalopathy (see ENCEPHALOPATHY, BOVINE SPONGIFORM); transmissible mink encephalopathy; and chronic wasting disease of mule deer and elk. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95 (23):13363-83)
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
Nearby Words
- transmissible gastroenteritis of swine
- transmissible gastroenteritis virus
- transmissible gastroenteritis virus, swine
- transmissible porcine gastroenteritides
- transmissible porcine gastroenteritis
- Transmissible Spongiform Encephalopathies
- transmissible spongiform encephalopathy
- transmissible venereal tumor
- transmissible venereal tumors
- transmission
- transmission channel