P16INK4A PROTEIN
\pˈiː sˈɪkstiːn ˌa͡ɪˌɛnkˈe͡ɪ fˈɔːɹ ˈe͡ɪ pɹˈə͡ʊtiːn], \pˈiː sˈɪkstiːn ˌaɪˌɛnkˈeɪ fˈɔːɹ ˈeɪ pɹˈəʊtiːn], \p_ˈiː s_ˈɪ_k_s_t_iː_n ˌaɪ_ˌɛ_n_k_ˈeɪ f_ˈɔː_ɹ ˈeɪ p_ɹ_ˈəʊ_t_iː_n]\
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A gene product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member the INK4 family - inhibitors of cyclin-dependent kinase CDK4. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is P14ARF PROTEIN. Both p16 gene products have tumor suppressor functions.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.