G PROTEIN ALPHA SUBUNIT
\d͡ʒˈiː pɹˈə͡ʊtiːn ˈalfə sˈʌbjuːnˌɪt], \dʒˈiː pɹˈəʊtiːn ˈalfə sˈʌbjuːnˌɪt], \dʒ_ˈiː p_ɹ_ˈəʊ_t_iː_n ˈa_l_f_ə s_ˈʌ_b_j_uː_n_ˌɪ_t]\
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GTP-BINDING PROTEINS that contain three non-identical subunits. They are found associated with members of the seven transmembrane domain superfamily of G-protein coupled receptors. The G-alpha subunit acts as a signal transduction molecule when it binds GTP and dissociates from the heterotrimer. Hydrolysis of GTP by the inherent GTPase activity of the protein causes it to revert to its inactive (heterotrimeric) form. EC 3.6.1.-.
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