FULMINANT HEPATIC FAILURE WITH CEREBRAL EDEMA
\fˈʊlmɪnənt hɛpˈatɪk fˈe͡ɪli͡ə wɪð səɹˈiːbɹə͡l ˈɛdɪmə], \fˈʊlmɪnənt hɛpˈatɪk fˈeɪliə wɪð səɹˈiːbɹəl ˈɛdɪmə], \f_ˈʊ_l_m_ɪ_n_ə_n_t h_ɛ_p_ˈa_t_ɪ_k f_ˈeɪ_l_iə w_ɪ_ð s_ə_ɹ_ˈiː_b_ɹ_əl ˈɛ_d_ɪ_m_ə]\
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A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); asterixis; NYSTAGMUS; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
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Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.