DNA UNTWISTING ENZYMES
\dˌiːˌɛnˈe͡ɪ ʌntwˈɪstɪŋ ˈɛnza͡ɪmz], \dˌiːˌɛnˈeɪ ʌntwˈɪstɪŋ ˈɛnzaɪmz], \d_ˌiː__ˌɛ_n_ˈeɪ ʌ_n_t_w_ˈɪ_s_t_ɪ_ŋ ˈɛ_n_z_aɪ_m_z]\
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DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.