4 HYDROXYAFLATOXIN B1
\fˈɔː hˈa͡ɪdɹəksɪˌaflɐtˌɒksɪn bˈiː wˈɒn], \fˈɔː hˈaɪdɹəksɪˌaflɐtˌɒksɪn bˈiː wˈɒn], \f_ˈɔː h_ˈaɪ_d_ɹ_ə_k_s_ɪ__ˌa_f_l_ɐ_t_ˌɒ_k_s_ɪ_n b_ˈiː w_ˈɒ_n]\
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A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
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Nearby Words
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