PROCOLLAGEN PROLINE DIOXYGENASE
\pɹə͡ʊkˈɒle͡ɪd͡ʒən pɹˈɒliːn da͡ɪˈɒksɪd͡ʒənˌe͡ɪs], \pɹəʊkˈɒleɪdʒən pɹˈɒliːn daɪˈɒksɪdʒənˌeɪs], \p_ɹ_əʊ_k_ˈɒ_l_eɪ_dʒ_ə_n p_ɹ_ˈɒ_l_iː_n d_aɪ_ˈɒ_k_s_ɪ_dʒ_ə_n_ˌeɪ_s]\
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A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl-containing-peptide, usually in protocollagen, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.